REFRACTi™ MASTER update

Biotech REFRACTimaster

REFRACTi™ MASTER update
The new REFRACTi™ MASTER RI detector from Biotech Fluidics excels in every aspect, and it is perfect for determination of compounds with low UV absorbance including simple sugars, complex carbohydrates, alcohols, fatty acids, and polymers.

With a 4.3” touch panel, intuitive user interface and features as extended temperature range up to 80 °C, this is a refractive index detector truly built for modern HPLC analysis. The detector do also have an automatic detection of sample path blockage, as well as a built-in overpressure safety assembly to prevent any cell breakage in case of blockage.

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MarvelXACT-Tight with a Click

MarvelXACT click

Reliable high-pressure connections every time

Reliable and reproducible fluid path connections is a fundamental requirement for meeting system suitability criteria in chemical analysis performed by high performance liquid chromatography (HPLC & UHPLC) equipment. Poor connections may lead to retention variability and decreased separation efficiency, thus ultimately determining if the analysis will satisfy regulatory demands including pharmacopoeia requirements, or instead fail. Since unreliable analytical results have no value at all and the samples then must be fully reprocessed, a poor fluid connection could even have impact on laboratory economy.

MarvelXACT achieves perfect leak-free fluid connections in HPLC & UHPLC by using a combination of innovative features. The pre-cut polished tube end seals efficiently and eliminates dead volumes. Moreover, the complete lack of any deforming ferrules ensures that the connection will fit to and can be moved between different port designs. Finally, the patented torque-limiting mechanism with “click” feedback ensures that every connection will have the same high performance. Built from sturdy, bioinert PEEK and stainless steel, the MarvelXACT fitting can be reconnected more than 100 times even at the most demanding positions such as column inlet.

In summary, MarvelXACT is the most cost-effective way to achieve perfect fluid column connection every time, thus increasing the probability that system suitability criteria can be met and that reliable analysis results can be delivered in a timely manner from your laboratory.

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Biotech Liquid Flow Meter

Determination of flow rates in liquid chromatography has traditionally been a tedious, inexact and manual task.
But not any longer. The new Biotech Liquid Flowmeter can continuously and accurately determine inline flow rates in any mode of liquid chromatography without interfering with the system. Being compatible with most solvents, a wide pH range, and pressures up to 3 MPa (435 psi), it is the perfect tool for high-precision measurement of flow rates ranging from 0.001 to 5 mL/min. Since it also is very easy to use, small enough to fit into your hand or lab coat pocket, and not weighing more than a cell phone, it might just become your best laboratory friend.
The Biotech Liquid Flowmeter comes pre-calibrated and can be connected inline in any orientation to continuously measure inline flow rates of liquids for instance during qualification of chromatography instruments. Via its USB interface and modern PC application, data can also be recorded as time series, which may be very helpful when identifying flow rate variations during troubleshooting of pumps, check valves or other malfunctioning components in liquid chromatography equipment.

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PEEKsil™ tubing with MarvelXACT™ fittings – Finger tight to 19 000 psi

Our bioinert PEEKsil™ tubing with MarvelXACT™ PEEKsil™ connection systems utilize patented MarvelXACT™ fittings for use in the most demanding UHPLC applications. The robust PEEKsil™ tubing has smooth silica glass wetted surfaces and is chemically compatible to organic solvents. Each connection system is individually cut, polished, and manufactured to provide industry leading technology that produces superior chromatographic results.

The MarvelXACT™ fitting features torque-limiting technology that is finger tight and provides a haptic “click” feedback when it reaches the optimum torque, assuring a perfect zero dead volume connection every time. The fitting can be connected and disconnected 100+ times. It incorporates flexible 1/32″ OD tubing for easy routing throughout your instrument and the connection system is compatible with 10-32 coned receiving ports and is absolutely finger-tight — no tool required.

MarvelXACT™ PEEKsil™ connection systems are available in ID 25, 50, 75, 100 µm and 150, 350, 600 mm length.

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BioVersal™ UHPLC Sample Loops

The BioVersal™ sample loops are 100% bioinert, making them ideal when injecting biological or “sticky” samples. These sample loops utilize our unique patented MarvelX technology to auto adjust to various port depths

  • Pressures up to 1310 bar (131 MPa; 19,000 psi)
  • No tools required – two fingertight MarvelX™  fittings are included
  • Zero dead volume and better chromatographic results
  • Volumes from 5 – 100 µl
  • Reusable and compatible with all 10-32 coned ports
  • Inert to almost all organic solvents
  • PEEK lined stainless steel
  • Metal-free

DEGASi® HIGH FLOW 1000

Biotech DEGASi® HIGH FLOW 1000

Efficient degassing of liquids at high flow rates has always been a tough challenge. Until now, that is.

Regardless if you work with process chromatography, have sensitive manufacturing processes in biotechnology, make advanced ink jet printing, perform critical dissolution testing, or design sophisticated dispensing equipment, the new Biotech DEGASi® HIGH FLOW 1000 eliminates problems with dissolved gases. With this impressive device, you can efficiently remove bubbles and dissolved gases from your water-based solutions up to 1000 mL/min.

Biotech DEGASi® HIGH FLOW 1000 is equipped with the new superior Systec® DST vacuum pump which ensures ultra-high degasification efficiency with low maintenance. Since this vacuum pump operates with very low vibrations, the Biotech DEGASi® HIGH FLOW 1000 is almost completely silent.

Being based on silicone-membrane technology, Biotech DEGASi® HIGH FLOW 1000 is mainly designed for aqueous liquids in application areas such as:
• Clinical chemistry analyzers
• Dispensing applications
• Dissolution testing
• Process applications
• High-throughput applications
• Ink degassing

Learn more about the new benchmark for high-throughput degasification applications at: DEGASi High Flow 1000

Introducing the <1100 ml Volumetric Precision Dispenser

 

Have you encountered issues dispensing larger volumes of liquids with high precision and accuracy?
Biotech introduces the Volumetric Precision Dispenser, a fast dispenser that makes it possible to repeatedly dispense larger volumes in a very easy and convenient way. Our new dispenser will save you a lot of time and you can be sure to get a perfect result. It operates via a display without any need of external computer and is compatible with almost all organic solvents.

Amongst the benefits are:

  • In the range of <30 – 1 100 ml you will get an exact dosage of liquid volumes.
  • You can repeat the set volume up to 999 times.
  • The standard deviation is <0.02.
  • Volume and precision accuracy: 30 – 300 ml <0,5 ml, 300 – 1100 ml <0.4%.
  • It can be operated from a touch panel without the need of a computer.
  • Easy to operate via touch panel. No computer needed.
  • Since the device has no contact with metal, it is corrosion resistant.
  • The dispenser can handle aggressive liquids and solvents.
  • It is also available for dilution purposes with extra valves.
  • The life time is outstanding.
  • Lower volume ranges, e.g., 500 ml are also available.

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New Application Dictionary

SunShell Applications 2018

Order the new Chromanik-Biotech Application Dictionary on USB stick or download it as pdf file.
This booklet contains over 120 application examples of how Chromanik HPLC and UHPLC columns solve separation and analysis problem and is the perfect tool to use for marketing and sales. Every example contains all the info to set up the separation, including mobile phase, flow rate, temperature and detection type. Most applications also come with chemical structural formula, making it easy for your customers to recognize molecules similar to their own.
Witness the true power of Chromanik HPLC and UHPLC columns. With a wide variety of column chemistries to choose from, including C18, C18-WP, HFC18-16, HFC18-30, RP-AQUA, CS, C30, PFP, Phenyl, CS-30, C8-30HT, C4-30, HILIC-Amide and 2-EP, even the most challenging analysis needs are likely to be solved.
SunShell Dictionary_Sida_112
This inspiring range of convincing separations will hopefully make you and other skilled chromatographers curious about the benefits that Chromanik HPLC and UHPLC columns can bring to your laboratories. In the Application Dictionary you can learn from interesting applications such as:
– LC/MS analysis of 213 pesticides within 15 minutes on a Sunshell C18 column (No. 1101B)
– High-throughput baseline separation of 8 components within less than 1 minute (No. 1033)
– Separation of 11 organic acids within 5 minutes using a fully aqueous mobile phase (No. 1059)
– Selectivity comparison of Sunshell C18, PFP and Phenyl columns using three toluidine isomers and acetonitrile or methanol as organic modifier in the mobile phase (No. 1125H)
If you cannot find a matching separation example in this Application Dictionary or have other questions about HPLC and UHPLC, you are most welcome to contact Biotech. Our aim is to guide you to the best column for every situation. The solution could be only an email or phone call away!

Download DictionaryOrder USB-Stick

MICRO/NANO-COLUMNS

Micro/Nano-columns

ChromaNik have released a range of Micro and Nano LC-MS columns with diameters from 0.5 mm down to 75 µm in different lengths. The columns are available with the SunShell high-performance core-shell materials in different particle sizes and with either C18 or Phenyl stationary phase chemistries. You can also choose the high-throughput material SunShell C8-30HT which has an exceptionally thin shell structure for extra fast separations, or the more traditional fully porous Sunniest material with C18 modification, or the SunShell C4-100 wide pore core-shell particles for separation of large molecules like monoclonal antibodies.

LC/MS/MSThe ChromaNik Micro and Nano columns are highly suitable for LC-MS/MS analysis. The columns can for example contribute to higher sequence coverage and higher identification rate when mapping a tryptic digest of a BSA protein, as shown in the example below. This was achieved thanks to an efficient separation with small peak elution volume, resulting in better discrimination and higher detection sensitivity.

IDEX RefractoMax RI Detectors

RefractoMax521-22-24

 

Accomplish sensitive and reliable detection of sugars, lipids, polymers and other compounds having low absorptivity in the UV-Vis range, by using the RefractoMax Refractive Index Detectors. This detector is perfect for:
• Alcohols
• Mono- and polysaccharides
• Fatty acids
• Polymers
• Compounds with low UV-Vis activity
Designed to be both powerful and user friendly. The RefractoMax is engineered to give very high baseline stability to deliver superior signal-to-noise ratio with neglectable drift even at long analysis times. This is accomplished by the optical bench which is thermostatically controlled between 30 °C to 55 °C.
Convenient features such as a leak sensor that automatically can switch off the pump and automated start-up, facilitates everyday use and method development. The Auto Set-up function automates purging, equilibration, autozero and control of baseline stability and noise. Instrument validation and calibration can also be carried out by the push of a button and instructions on the coloured display screen. Easy integration with different chromatography systems is ensured by the ports for external input and output communication.
Because the RefractoMax is available in three different configurations there is always a model that fit your needs. The 524 Micro version is optimized for operation together with small ID HPLC columns used at low flow rates, and the 521 Analytical model is designed for highest detection sensitivity with standard HPLC column separations. The RefractoMax 522 Semi-Prep is suitable for higher flow rates and has a wider dynamic range to handle more concentrated samples.

RefractoMax524RefractoMax521RefractoMax522
RefractoMax 524 Micro RefractoMax 521 AnalyticalRefractoMax 522 Semi-Prep
• 0.1 to 1 mL/min
• 2.5 µL flow cell
• High sensitivity
• 1 to 5 mL/min
• 8 µL flow cell
• High sensitivity
• 1 to 50 mL/min
• 8 µL flow cell
• Wide dynamic range