Swedish National Day, June 6

Swedish Midsummer

We would like to inform you that our office in Sweden will be closed on National Day, June 6. We apologize for any inconvenience and look forward to serving you friday June 7. Thank you for your understanding!

Meet Biotech Fluidics at Pittcon 2024

Stop by to visit Biotech Fluidics at Booth 2018 during Pittcon 2024 in San Diego, USA.

Talk to our fluidic experts and learn more about:

  • Biotech Liquid Flow Meter – provides continuous measurement of flow rate for many fluids in a wide flow rate range
  • REFRACTiMASTER® powerful refractive index detector that is perfect for determination of compounds with low UV absorbance
  • DEGASi® Integration series – efficient degassers for most types of fluid, which also allow monitoring of vacuum level for full system integration
Welcome to Booth 2018!

Now we are Biotech Fluidics AB

Our official name is now Biotech Fluidics AB (previous official name “Biotech i Kungsbacka AB”).This has been done to better reflect our business and our domain name www.biotechfluidics.com. You will soon see the new name on our quotes, orders and invoices etc. Nothing else has changed!

The VAT number remains the same, as well as our address and all our contact details. However, you will start seeing our updated logo as well as graphic profile. The name change is not affecting our offices in USA and Japan. We are looking forward to a mutual fruitful co-operation during the year.

Fritiof Pontén, CEO – Anders Grahn, Founder/Chairman of the Board

Automated flow chemistry cooperation

During 2023, Biotech Fluidics was selected by AutoSyn AB to work on a series of enhancements for their Autonomous Chemistry Lab flow chemistry system. The Autonomous Chemistry Lab, developed at Chalmers Technical University, Gothenburg, and commercialized by AutoSyn AB, is creating a transformative new way of doing chemistry where reaction sequences for chemical compounds are developed faster and with less resource waste than has been possible. This is achieved by combining flow chemistry methods with analytical tools and supporting AI algorithms, leading to reduced amounts of materials and time required for each process cycle.

Hannes Schomaker, co-founder and CTO of AutoSyn AB, said “We have partnered with Biotech Fluidics since the early days of starting our company. Their broad technical and application expertise, and willingness to discuss, explain and develop novel solutions, has made our cooperation a success. We have been very satisfied with Biotech´s services and are looking forward to a continued fruitful partnership and are already working on the next projects.”

Our CEO, Fritiof Pontén replied “We were delighted to be chosen by AutoSyn AB to help solve multiple challenges in their product development. At Biotech Fluidics we have in-depth expertise in developing high performance solutions for fluidic systems and find a pleasure in providing the best possible support to OEM’s and developers to access the full potential of their instruments.”

For more information on the Autonomous Chemistry Lab and the services that AutoSyn AB offers, please visit their website www.autosyn.se or get in contact via email info@autosyn.se. For assistance with your fluidic setup, contact Biotech Fluidics at: info@biotechfluidics.com

Biotech Micro Flow Meter           nl/min – 80µl/min

Optimized to operate over the 100nl to 80 µL/minute flow range, with an unmatched high resolution of 1nl / minute, the Micro Flow Meter is the perfect tool for continuous monitoring the consistency of UHPLC, LC/MS, high precision flow cytometry and micro- / nanoscale fluidics applications.
The Micro Flow Meter is compatible with almost any solvent and being non-invasive guarantees the unperturbed operation of your whole fluidic system. You can continuously monitor fluidic flows in your system and get pump performance diagnostics at the same time. Flow pulsation as well as drift in your fluidic system will be easy to find.
Easy-to-use PC software enabling continuous recording, monitoring, and storage of measured flow rate data.

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Enhancing SPR instrument performance

Biotech Fluidics AB reports that it is supplying key microfluidic and degassing components to BioNavis Oy (Tampere, Finland) for its range of Multi-Parametric Surface Plasmon Resonance (MP-SPR) instruments.

Surface Plasmon Resonance is the ‘go to’ technique for the measurement of molecular interactions in fluidics including serum, saliva, and organic solvents. SPR technology beneficially allows evaluation of affinity and kinetics of molecular binding reactions without the burdens of labelling as the technique is label-free.
The BioNavis Navi™ range of advanced MP-SPR instruments provide superior features and performance enabling both studies of surface interactions as well as nanolayer characterization. Navi MP-SPR instruments are helping scientists with antibody characterization through drug uptake routes, controlled drug release strategies, small molecule measurements, nanoparticle targeting up to drug internalization by living cells.

Jussi Tuppurainen, Technical Director of BioNavis commented “The key part of our MP-SPR fluidics systems are IDEX port selection valves supplied by Biotech Fluidics. These high-quality valves contribute to precise handling of samples, allowing researchers to control the timing, volume, and flow rate of injected liquids. This precision is vital for achieving reproducible results and minimizing variations in sample concentration. Additionally, the Degasser system supplied by Biotech Fluidics helps maintain sample integrity by preventing the introduction of air bubbles, which can disrupt measurements. Careful fluidic design and efficient degassing techniques eliminate bubbles and preserve the stability of the sample, ensuring reliable data”.

In conclusion – Jussi Tuppurainen said “BioNavis has been a satisfied customer of Biotech Fluidics for many years. We highly recommend them not only for their top-quality products, but also because of the consistently professional and friendly customer service they provide.”

For more information on fluidic components for SPR instruments please visit https://www.biotechfluidics.com/products/idex-catalogue/.
For further information on a degasser for your SPR system please visit www.biotechfluidics.com/products/degassing-debubbling/ or contact Biotech Fluidics on + 46 300 56 91 80 / + 612-703-5718 / info@biotechfluidics.com.

For further information on the Navi™ range of advanced MP-SPR instruments please visit https://www.bionavis.com/en/.

DEGASi® HFIP

DEGASi® HFIP

The toughest degasser

Biotech Fluidics has recently launched a new model of inline degassers, designed for full compatibility with the toughest solvents. We named it DEGASi® HFIP since it can withstand the highly aggressive solvent hexafluoro isopropanol (HFIP) that is used in liquid chromatography separations of certain polymers and peptides that are difficult to dissolve otherwise. The DEGASi® HFIP inline degasser is compatible with a range of volatile and aggressive solvents, including hexafluoro isopropanol and silanes, but can certainly also manage all other solvents used for gel permeation chromatography (GPC) and size exclusion chromatography (SEC).

Available with two different degassing chambers for analytical and semi-preparative applications, the DEGASi® HFIP can handle flow rates up to 3 and 6 mL/min, respectively. This inline degasser also comes with the new integration feature, meaning that it provides an output signal corresponding to the internal vacuum level (5 mV/mmHg), thus enabling continuous direct monitoring by instrument assemblies and software.

For more information about the new DEGASi® HFIP model of inline degassers, or to discuss the selection of degasser for your application, please contact Biotech Fluidics.

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Degassers for your ÄKTA system

DEGASi(R) Prep Äkta

Equipment for preparative purification of tagged and untagged proteins, including the ÄKTA series of liquid chromatography systems from Cytiva Life Sciences, are frequently used in settings ranging from scientific research laboratories to production plants. With these systems, it is possible to perform a variety of chromatographic separation modes including affinity, size exclusion, gel filtration, hydrophobic interaction, reversed phase, and ion exchange. However, in all modes and setups, the formation of bubbles may hamper the reproducibility of purification results and thus limit the overall productivity.

Bubbles form because of high levels of dissolved gases in the employed buffers and solvents. The multiple pressure drops occurring within the liquid flow path through a chromatography system (injector valves, separation column, detector cell, etc.), may initiate bubble formation, especially if any segment also has a higher temperature compared to the eluent bottle. Traditional ways of removing dissolved gases have been to treat the buffers, eluents and mobile phases in ultrasonic baths, but this is both labour intensive and rather inefficient, and risk changing the solution temperature, or may even accelerate degradation of sensitive components. The most efficient and user-friendly way to remove bubbles and dissolved gases in liquid chromatography is by using inline vacuum degassers.

The DEGASi® range of inline vacuum degassers from Biotech Fluidics can be fitted to any brand of liquid chromatography instruments to solve all your troubles with bubbles. The DEGASi® PREP stand-alone degasser is designed for flow rates up to about 20 ml/min per channel and thus suitable for most of the laboratory protein purification chromatography systems including ÄKTA start, ÄKTA go, ÄKTA pure 25 and ÄKTA avant 25, plus discontinued legacy systems such as ÄKTAprime plus, ÄKTAxpress ÄKTA Purifyer and ÄKTA FPLC (some these models were built by GE Healthcare or Amersham Pharmacia Biotech). Several alternative DEGASi® degasser designs are available for chromatography systems with higher or lower flow rate specifications.

Please contact Biotech Fluidics for any questions or concerns regarding what degasser best would suit your needs in terms of flow rates and solvent compatibility.
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Tubing kits for dissolution testing

Did you know that Biotech Fluidics custom manufacture tubing kits for dissolution testing equipment and for other purposes?

In pharmaceutical dissolution testing, the solution into which the medication is gradually dissolved, is sampled repeatedly over a certain time period at standardised conditions, to determine the rate of release of an active ingredient. Instruments for these tests are typically designed to perform several parallel experiments in separate vessels. Although sampling could be performed manually, automatic sampling and analysis allow for considerably increased throughput. Automatic sampling typically requires multiple transfer lines to be connected to each vessel for sample withdrawal. This may quickly build up to handling many different sorts of tubing and fitting components to stock for a certain system. Purchasing pre-made tubing kits from Biotech Fluidics can help you simply the setup and execution of these test.

Our long experience in inert and chemically resistant tubing and first-class fittings for a wide variety of requirements, combined with a high-quality assembly line with skilled staff, makes Biotech Fluidics your perfect partner for any tubing kit manufacturing. Tubing kits can be adapted to fit any brand dissolution instrument on the market, including for example Agilent, Bioevopeak, Distek, Electrolab, Erweka, Hanson, Logan, Pharmtest, Sotax, Teledyne, Toron, and certainly also to other types of instruments. Contact Biotech Fluidics to discuss your specific requirements.

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Integrate your degasser

DEGASi Integration

Biotech Fluidics has recently launched a new series of DEGASi® inline degassers, designed for integration into analytical or production instrument assemblies. The new degassers are featured with an electronic validation output signal that corresponds to the level of vacuum within the degasser (5 mV/mmHg). This quality allows your instrument software to continuously monitor the degasser performance and present that to the user. If the vacuum level would not meet the set requirements, this feature enables providing the user with adequate warnings or even prevent certain instrument events. This ability to integrate monitoring of your degasser performance is in line with recent regulatory demands regarding instrument performance qualification and is for example aligning with the United States Pharmacopoeia (USP) general chapter 1058.

For more information about this new series of DEGASi® Integration degassers with validation output, or to discuss the selection of degasser for your application, please contact Biotech Fluidics.

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